Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function

碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 98 === In the previous study, we demonstrated that Ocimum gratissimum could inhibit HSC activation. Moreover, the purified Ocimum gratissimum also inhibited the CCl4-induced liver fibrosis.The purpose of this request research program is to determine the hepaprotectiv...

Full description

Bibliographic Details
Main Authors: Hsueh-Hui, 李雪惠
Other Authors: Shao-Hsuan Kao
Format: Others
Language:zh-TW
Published: 2010
Online Access:http://ndltd.ncl.edu.tw/handle/46201947813965921149
id ndltd-TW-098CSMU5107040
record_format oai_dc
spelling ndltd-TW-098CSMU51070402015-10-28T04:07:07Z http://ndltd.ncl.edu.tw/handle/46201947813965921149 Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function 七層塔萃取粉 10%(Ocimum gratissimum)對肝功能功效性之動物試驗 Hsueh-Hui 李雪惠 碩士 中山醫學大學 生化暨生物科技研究所 98 In the previous study, we demonstrated that Ocimum gratissimum could inhibit HSC activation. Moreover, the purified Ocimum gratissimum also inhibited the CCl4-induced liver fibrosis.The purpose of this request research program is to determine the hepaprotective effect of Chhit-Chan-Than extract powder 10% (Ocimum gratissimum). First, we determined the toxicity of Chhit-Chan-Than extract powder 10%. After 28 days of continuous tube feeding with different dose of Chhit-Chan-Than extract powder 10%, the results of biochemistry、urine biochemistry and hematology were no change. Therefore, we suggested that Chhit-Chan-Than extract powder 10% was safety in vivo. Furthermore, we investigated the hepaprotective effects of Chhit-Chan-Than extract powder 10% in vivo. The results indicated that the CCl4-induced histopathogical changes may be prevented by the Chhit-Chan-Than extract powder 10% through reducing the intercellular collogen stack, dropping blood serum ALT and AST levels; and replying the catalase activity and GSH content (the anti-oxidative enzyme activity and the anti-oxidative ingredient). Although Chhit-Chan-Than extract powder 10% has not completed to resume the formation of liver fibrosis induced by CCl4, the suppression of Chhit-Chan-Than extract powder 200 mg/Kg was nearly similar to the silymarin. Take together; we suggested that the Chhit-Chan-Than extract powder 10% was able to prevent the liver inflammation and fibrosis. Shao-Hsuan Kao 高紹軒 2010 學位論文 ; thesis 99 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 98 === In the previous study, we demonstrated that Ocimum gratissimum could inhibit HSC activation. Moreover, the purified Ocimum gratissimum also inhibited the CCl4-induced liver fibrosis.The purpose of this request research program is to determine the hepaprotective effect of Chhit-Chan-Than extract powder 10% (Ocimum gratissimum). First, we determined the toxicity of Chhit-Chan-Than extract powder 10%. After 28 days of continuous tube feeding with different dose of Chhit-Chan-Than extract powder 10%, the results of biochemistry、urine biochemistry and hematology were no change. Therefore, we suggested that Chhit-Chan-Than extract powder 10% was safety in vivo. Furthermore, we investigated the hepaprotective effects of Chhit-Chan-Than extract powder 10% in vivo. The results indicated that the CCl4-induced histopathogical changes may be prevented by the Chhit-Chan-Than extract powder 10% through reducing the intercellular collogen stack, dropping blood serum ALT and AST levels; and replying the catalase activity and GSH content (the anti-oxidative enzyme activity and the anti-oxidative ingredient). Although Chhit-Chan-Than extract powder 10% has not completed to resume the formation of liver fibrosis induced by CCl4, the suppression of Chhit-Chan-Than extract powder 200 mg/Kg was nearly similar to the silymarin. Take together; we suggested that the Chhit-Chan-Than extract powder 10% was able to prevent the liver inflammation and fibrosis.
author2 Shao-Hsuan Kao
author_facet Shao-Hsuan Kao
Hsueh-Hui
李雪惠
author Hsueh-Hui
李雪惠
spellingShingle Hsueh-Hui
李雪惠
Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
author_sort Hsueh-Hui
title Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
title_short Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
title_full Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
title_fullStr Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
title_full_unstemmed Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
title_sort animal test of the efficacy of chhit-chan-than (ocimum gratissimum) extract powder 10% for hepatic function
publishDate 2010
url http://ndltd.ncl.edu.tw/handle/46201947813965921149
work_keys_str_mv AT hsuehhui animaltestoftheefficacyofchhitchanthanocimumgratissimumextractpowder10forhepaticfunction
AT lǐxuěhuì animaltestoftheefficacyofchhitchanthanocimumgratissimumextractpowder10forhepaticfunction
AT hsuehhui qīcéngtǎcuìqǔfěn10ocimumgratissimumduìgāngōngnénggōngxiàoxìngzhīdòngwùshìyàn
AT lǐxuěhuì qīcéngtǎcuìqǔfěn10ocimumgratissimumduìgāngōngnénggōngxiàoxìngzhīdòngwùshìyàn
_version_ 1718113225499738112