Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function
碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 98 === In the previous study, we demonstrated that Ocimum gratissimum could inhibit HSC activation. Moreover, the purified Ocimum gratissimum also inhibited the CCl4-induced liver fibrosis.The purpose of this request research program is to determine the hepaprotectiv...
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ndltd-TW-098CSMU51070402015-10-28T04:07:07Z http://ndltd.ncl.edu.tw/handle/46201947813965921149 Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function 七層塔萃取粉 10%(Ocimum gratissimum)對肝功能功效性之動物試驗 Hsueh-Hui 李雪惠 碩士 中山醫學大學 生化暨生物科技研究所 98 In the previous study, we demonstrated that Ocimum gratissimum could inhibit HSC activation. Moreover, the purified Ocimum gratissimum also inhibited the CCl4-induced liver fibrosis.The purpose of this request research program is to determine the hepaprotective effect of Chhit-Chan-Than extract powder 10% (Ocimum gratissimum). First, we determined the toxicity of Chhit-Chan-Than extract powder 10%. After 28 days of continuous tube feeding with different dose of Chhit-Chan-Than extract powder 10%, the results of biochemistry、urine biochemistry and hematology were no change. Therefore, we suggested that Chhit-Chan-Than extract powder 10% was safety in vivo. Furthermore, we investigated the hepaprotective effects of Chhit-Chan-Than extract powder 10% in vivo. The results indicated that the CCl4-induced histopathogical changes may be prevented by the Chhit-Chan-Than extract powder 10% through reducing the intercellular collogen stack, dropping blood serum ALT and AST levels; and replying the catalase activity and GSH content (the anti-oxidative enzyme activity and the anti-oxidative ingredient). Although Chhit-Chan-Than extract powder 10% has not completed to resume the formation of liver fibrosis induced by CCl4, the suppression of Chhit-Chan-Than extract powder 200 mg/Kg was nearly similar to the silymarin. Take together; we suggested that the Chhit-Chan-Than extract powder 10% was able to prevent the liver inflammation and fibrosis. Shao-Hsuan Kao 高紹軒 2010 學位論文 ; thesis 99 zh-TW |
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碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 98 === In the previous study, we demonstrated that Ocimum gratissimum could inhibit HSC activation. Moreover, the purified Ocimum gratissimum also inhibited the CCl4-induced liver fibrosis.The purpose of this request research program is to determine the hepaprotective effect of Chhit-Chan-Than extract powder 10% (Ocimum gratissimum). First, we determined the toxicity of Chhit-Chan-Than extract powder 10%. After 28 days of continuous tube feeding with different dose of Chhit-Chan-Than extract powder 10%, the results of biochemistry、urine biochemistry and hematology were no change. Therefore, we suggested that Chhit-Chan-Than extract powder 10% was safety in vivo. Furthermore, we investigated the hepaprotective effects of Chhit-Chan-Than extract powder 10% in vivo. The results indicated that the CCl4-induced histopathogical changes may be prevented by the Chhit-Chan-Than extract powder 10% through reducing the intercellular collogen stack, dropping blood serum ALT and AST levels; and replying the catalase activity and GSH content (the anti-oxidative enzyme activity and the anti-oxidative ingredient). Although Chhit-Chan-Than extract powder 10% has not completed to resume the formation of liver fibrosis induced by CCl4, the suppression of Chhit-Chan-Than extract powder 200 mg/Kg was nearly similar to the silymarin. Take together; we suggested that the Chhit-Chan-Than extract powder 10% was able to prevent the liver inflammation and fibrosis.
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Shao-Hsuan Kao |
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Shao-Hsuan Kao Hsueh-Hui 李雪惠 |
author |
Hsueh-Hui 李雪惠 |
spellingShingle |
Hsueh-Hui 李雪惠 Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function |
author_sort |
Hsueh-Hui |
title |
Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function |
title_short |
Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function |
title_full |
Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function |
title_fullStr |
Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function |
title_full_unstemmed |
Animal test of the efficacy of Chhit-Chan-Than (Ocimum gratissimum) extract powder 10% for hepatic function |
title_sort |
animal test of the efficacy of chhit-chan-than (ocimum gratissimum) extract powder 10% for hepatic function |
publishDate |
2010 |
url |
http://ndltd.ncl.edu.tw/handle/46201947813965921149 |
work_keys_str_mv |
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