The effect of diluents on the swelling force

• Main Authors: Tsung-Yueh Tsai, 蔡宗岳
• Other Authors: Chun-Ren Chen
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/46172752150741629811

碩士 === 嘉南藥理科技大學 === 藥物科技研究所 === 98 === The tablet dosage form is the most popular pharmaceutical dosage form. It comprises a mixture of active substances and excipients compacted into a solid. The direct compression method is the most convenient method. The excipients usually include diluents and disintegrants. A disintegrant is commonly included in an immediate release tablet to enhance the disintegration of the tablet. The efficiency of a disintegrant is usually ascribed to its water uptake and swelling ability. The water-induced swelling force plays an important role in the disintegration of tablets. However, the effect of diluents on the swelling force has not been studied. The purpose of this study is to investigate the effect of excipients on the swelling force. Dicalcium phosphate dihydrate, microcrystalline cellulose, and mannitol were chosen as model diluents. Hydrochlorothiazide was chosen as a model drug. The disintegration test and the dissolution test were also conducted in the pH 1.2 HCl buffer and the pH 6.8 phosphate buffer to discuss the mutual relationships. The results show that the tablet containing a disintegrant and dicalcium phosphate dihydrate has the best disintegration and dissolution although the tablet containing a disintegrant and microcrystalline cellulose has higher swelling force.