Chemical and Biological Investigations of Muehlenbeckia platyclada

• Main Authors: Mong Ying Yang, 楊孟穎
• Other Authors: Y. L. Leu
• Format: Others
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/68441731044894720273

碩士 === 長庚大學 === 中醫學系天然藥物 === 98 === Muehlenbeckia platyclada is one species of Muehlenbeckia plants (Polygonaceae) in Guinea and Solomon Islands. In the cell viability experiment, the methanolic and ethyl acetate crude extracts showed the cytotoxic efficacy against human lung carcinoma cell line (A549) at 30 μg/ml. The viable percent of A549 treated with methanolic crude extract and ethyl acetate layer were 66.23 % and 55.68 %, separately. The dried whole plant of M. platyclada (6 Kg) were shattered, then extracted with methanol and then filtered. The filtrate was concentrated under reducing pressure to give dark brown extract at last. The crude extract was partitioned with water, ethyl acetate, and n-butanol, separately. All layers were chromatographed on column chromatography, thin layer chromatography, and ecrystallized to afford 40 compounds. Among them, 32 compounds were determined their structures by spectral analysis and compared with literature data. The major components of M. platyclada were flavonols.