| Summary: | 碩士 === 長庚大學 === 化工與材料工程學系 === 98 === The study proposes a straightforward strategy for the synthesis of novel, amphamiphilic block-graft (PLA)-b-P(αN3CL-g-alkyne) degradable copolymers. The ring-opening reaction of lactide was performed by using 1-hexanol as initiator and SnOct2 as catalyst. In the second step, pendent chlorides were converted into azides by reaction with sodium azide. Finally, alkynes were reacted with pendent azides by copper-catalyzed Huisgen’s 1,3-dipolar cycloaddition, thus a “click reaction”. These copolymers were characterized by 1H NMR，DSC and GPC. CMC values were detected by fluorescence probe technique. An increase of the length of hydrophobic segment in amphophilic block-graft copolymers produced a higher CMC values. The block-graft copolymers formed micelles in the aqueous phase with critical micelle concentrations (CMCs) in the range of 2.7-24.6 g/L. The morphology of the micelles exhibited a spherical shape depending on the length of PαN3CL-g-alkyne block. DLS experiments showed that the mean hydrodynamic diameters of the micelles were 106-297 nm. The drug loading content and drug entrapment efficiency decrease when the length of PαN3CL-g-alkyne block increased.
|
|---|
