amarium Diiodide-Mediated Reductive Intramolecular Cyclization in Spirane Synthesis
碩士 === 國立中正大學 === 化學所 === 98 === This thesis describes a methodology designed to access spiro compounds in a rapid and efficient manner. Treatment of β-methoxycycloalkenones 68 with Grignard reagent which were prepared from bromides 70 and magnesinm, follow by acidic aqueous workup provided enone-al...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2010
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| Online Access: | http://ndltd.ncl.edu.tw/handle/44264074441517770644 |
| Summary: | 碩士 === 國立中正大學 === 化學所 === 98 === This thesis describes a methodology designed to access spiro compounds in a rapid and efficient manner. Treatment of β-methoxycycloalkenones 68 with Grignard reagent which were prepared from bromides 70 and magnesinm, follow by acidic aqueous workup provided enone-aldehyedes 61. Enone-aldehyedes were then subjected to samarium diiodide under mild conditions and obtained various apirocyclic hydrocarbons 67 in good yields. Oxidation of hydroxyketone 67 with PCC afforded spirodiketone 62.
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