THE STUDY TO EVALUATE EFFECT OF SIMULATING DRY POWDER INHALER EMITTED THROUGH TRACHEOSTOMY TUBE

• Main Authors: Lan-Ti Chou, 周蘭娣
• Other Authors: Chung-Yih Wang
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/69724758523383243081

碩士 === 大同大學 === 生物工程學系(所) === 97 === The respiratory tract is one of the oldest routes for the administration of drugs more than 4000 years ago. Treatment of asthma by inhaled sympathetic agents began in earnest in the 1950s, and now such ‘topical’ or targeted treatment with inhaled drugs is considered for treating many other lung diseases. The drugs delivery by inhalation can be delivered with very rapid action, low metabolism and high bioavailability; and decreased systemic effects than intravenous injection. Dry powder inhaler formulation and delivery devices development and improvement in recently. But Patients with respiratory failure are often unable to inhale powdered aerosol medications such as long-acting anticholinergic agent- Tiotropium, which are important treatments for chronic obstructive pulmonary disease and asthma. With a proper interface, powdered long-acting agonists and long-acting anticholinergics can be easily delivered via tracheostomy tube. It is important to improved continuity and quality of care. This experiment selected a proper interface to evaluated effect of simulating dry powder inhaler emitted through tracheostomy tube. We estimates may the powdered long-acting anticholinergics can deliveried to the lungs.