Electrospinning of sulfonated chitosan/ polyvinyl alcohol nanofibrous membrane and application of antibacterial

• Main Authors: Hsui-Yi Hung, 洪琇議
• Other Authors: 芮祥鵬
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/55qpms

碩士 === 國立臺北科技大學 === 有機高分子研究所 === 97 === Chitosan is a biodegradable material that has attracted enormous attention in agricultural, pharmaceutical and medical industry due to its good biocompatibility and excellent physical and chemical properties. The purpose of this research is to modify chitosan structure via a chemical method. The modified chitosan has sulfonic acid group, the solubility of chitosan in water is significantly improved.Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers and various polymers have been successfully electrospun into ultrafine fibers during the last few years. Composite nanofiber membranes of sulfonated chitosan and PVA were the materials using water as a solvent by electrospinning in this study as an nanofiber membrane. Non-beaded and uniform nanofibers from the following optimum condition:10%PVA solution with 1~3wt% sulfonated chitosan was successfully electrospun at 15 kV operating voltage and nozzle to collector distance of 10cm, and application of antibacterial. The results, it showed that sulfonated chitosan/PVA membranes containing 2wt% sulfonated chitosan could inhibit the growth of staphylococcus. Finally, the sulfonated chitosan is crosslinked with glutaraldehyed to form membranes of networks. In the TGA、DSC analysis demonstrated that the nanofiber membranes of sulfonated chitosan/PVA membranes of sulfonated chitosan networks can increase sulfonic acid group in the structure are thermal stability and the glass transition temperature .In the mechanical properties, the result indicated that cross-linking with glutaraldehyde improves stress and decreases strain of the nanofiber membrane.