The Preparation and Characterization of Magnetic Gelatin/CaP Nanospheres as Thermoseed for Cancer Hyperthermia

• Main Authors: Zih-Yi Jhan, 詹子毅
• Other Authors: 許淙慶
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/6fqykh

碩士 === 國立臺北科技大學 === 材料科學與工程研究所 === 97 === Hyperthermia cancer treatment as therapy is popular in biotherapy field. Cancer cells are sensitive to heat. As temperature rise to 43~46℃, the heat treatment will cause cancer cells death. When magnetic nanoparticles is placed around cancar cells at an AC magnetic field, hysteresis loss will make temperature rise to 43℃ then kill cancer cells. The method is called magnetic hyperthermia. Calcium phosphate ( CaP ) is main mineral of bone and teeth, which is non-toxic, biocompatibility and biodegradable. In this study, the Fe2+ is doped into calcium phosphate to substitute Ca2+. Iron calcium phosphate ( calcium phosphate doped iron Fe( II ) ) can release heat in alternating magnetic field because it has magnetism. In the preparation process, gelatin is added because it has a lot of functional groups. In this study, iron calcium phosphate-gelatin nanoparticles is prepared by reverse micelle, using three phases system: n-hexane, AOT, water, and temperature is set at 25℃ while pH is set at weak acid around 5. CaP-Fe/gelatin nanoparticles is placed at an AC magnetic field, the heat is liberated due to hysteresis loss. It is believed that CaP-Fe/gelatin nanoparticles is one of the most potential materials in magnetic intracellular hyperthermia in the future.