| Summary: | 碩士 === 國立臺北科技大學 === 生物科技研究所 === 97 === Skin, one of the largest organs in human body, covers whole body surface and functions as a first line of defense mechanisms against the invasion of foreign microbes. Once the integrity of skin is disrupted by an open wound, the protective barrier is lost and the wounded area could provide an entry site for the foreign microorganisms. Microbial infection will perturb and delay the progression of normal wound healing and causes the chronicity of cutaneous wound. Severe infection could cause extensive tissue necrosis, amputation, systemic sepsis, and death.
In general, most of commercial wound dressings deal with either wound infection or wound healing. To control infection and improve wound healing simultaneously, we constructed a dressing combined with collagen and silver compounds. Collagen is a major component of connective tissues and plays an important role in normal wound healing, especially in the granulation phase. The advantages of collagen include high biocompatibility, non-cytotoxicity, low immunogenicity, biodegradability, and bioresorption. Collagen is also attractive to be a flexible drug delivery system. The silver compounds have powerfully antimicrobial activity against a broad spectrum of microbes, including common wound pathogens. We also establish the in vitro antimicrobial tests and an in vivo infected wound model to assay the antimicrobial efficacy of this dressing. In summary, we demonstrated the dressing comprised of both collagen and silver compounds not only effectively controlled the infection but also significantly promoted the wound healing.
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