Semiparametric Estimation of the Cumulative Incidence Function Under Competing Risks and Left-truncated Sampling

碩士 === 東海大學 === 統計學系 === 97 === Let (T1; T2) denote the lifetimes of two competing risks of interest and can be dependent on each other. Let V and (T3;C) denote left truncation and right censoring variables, respectively, where C denotes the censoring time due to termination of the follow-up period,...

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Bibliographic Details
Main Authors: Yi-chen Yang, 楊易蓁
Other Authors: Pao-sheng Shen
Format: Others
Language:en_US
Published: 2009
Online Access:http://ndltd.ncl.edu.tw/handle/44779438231155646417
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Summary:碩士 === 東海大學 === 統計學系 === 97 === Let (T1; T2) denote the lifetimes of two competing risks of interest and can be dependent on each other. Let V and (T3;C) denote left truncation and right censoring variables, respectively, where C denotes the censoring time due to termination of the follow-up period, and T3 is the censoring time due to a failure other than the two failures of interest, which might occur before the cross-section time. Assume that (T1; T2), (V;C) and T3 are independent of one another other but V and C are dependent with P(C _ V ) = 1. Let aG denote the left support of V . In application, due to truncation, some a > aG is selected so that the size of the observed risk set at a is not too small. Let _1(xja) = P(T1 _ x; T1 _ T2jT1 > a; T2 > a) and _2(xja) = P(T2 _ x; T2 _ T1jT1 > a; T2 > a) denote the conditional cumulative incidence function of T1 and T2, respectively. When V is uniformly distributed and C = T3 = 1, Huang and Wang (1995) proposed a semiparametric estimator of _k(xj0). In this article, we extend previous models by considering the case when the distribution of V is parameterized as G(x; _) and the distributions of Tk and C are left unspeci_ed. Several iterative algorithms are proposed to obtain the semiparametric estimates (denoted by _k(x; ^_nja)) of _k(xja). The consistency of _k(x; ^_nja) is derived. Simulation results show that the semiparametric estimators _k(x; ^_nja) have smaller mean squared errors compared to the nonparametric maximum likelihood estimator of _k(xja).