Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten

Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten

碩士 === 東海大學 === 化學系 === 97 === English Abstract This thesis described the design, synthesis, and evaluation of three different types of compounds as potential DNA cutting agents. Type I includes: compound 2 ( 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone ), compound 4 ( 2,5- Dimethoxy-hydroqu...

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Main Authors: Lu ya hui, 呂雅惠
Other Authors: Yang ding ya
Format: Others
Language:zh-TW
Published: 2008
Online Access:http://ndltd.ncl.edu.tw/handle/88210925915832722261
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spelling ndltd-TW-097THU000650052015-10-13T14:49:20Z http://ndltd.ncl.edu.tw/handle/88210925915832722261 Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten 設計及合成以DMQ-MA為主體的胜肽衍生物作為潛在之DNA切割試劑 Lu ya hui 呂雅惠 碩士 東海大學 化學系 97 English Abstract This thesis described the design, synthesis, and evaluation of three different types of compounds as potential DNA cutting agents. Type I includes: compound 2 ( 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone ), compound 4 ( 2,5- Dimethoxy-hydroquinone-3-mecraptoacetic acid ) and compound 8 ( 2-(hydroxy(phenyl)methyl)-5-methoxycyclohexa-2,5-diene-1,4-dione ), which failed to exhibit any DNA cutting ability, based on the agarose gel electrophoresis studies. This result suggested that substitutents on the benzoquinone moiety play a pivotal role on their reactivity with DNA. Types II and III include DMQ-MA-Leu-Arg-OMe 19 and DMQ-MA-Gln-Arg-OMe 21. They were prepared by coupling of DMQ-MA with Leu-Arg-OMe and Gln-Arg-OMe, respectively. The structures of 19 and 21 were confirmed by mass spectroscopy. Electrophoresis studies indicated that both 19 and 21 possess DNA cutting capability at the concentration of 0.5 M. The latter displayed better DNA cutting ability than the former presumably due to the hydrophilic character of the amino acid glutamine. Yang ding ya She liang 楊定亞 佘亮 2008 學位論文 ; thesis 102 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 東海大學 === 化學系 === 97 === English Abstract This thesis described the design, synthesis, and evaluation of three different types of compounds as potential DNA cutting agents. Type I includes: compound 2 ( 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone ), compound 4 ( 2,5- Dimethoxy-hydroquinone-3-mecraptoacetic acid ) and compound 8 ( 2-(hydroxy(phenyl)methyl)-5-methoxycyclohexa-2,5-diene-1,4-dione ), which failed to exhibit any DNA cutting ability, based on the agarose gel electrophoresis studies. This result suggested that substitutents on the benzoquinone moiety play a pivotal role on their reactivity with DNA. Types II and III include DMQ-MA-Leu-Arg-OMe 19 and DMQ-MA-Gln-Arg-OMe 21. They were prepared by coupling of DMQ-MA with Leu-Arg-OMe and Gln-Arg-OMe, respectively. The structures of 19 and 21 were confirmed by mass spectroscopy. Electrophoresis studies indicated that both 19 and 21 possess DNA cutting capability at the concentration of 0.5 M. The latter displayed better DNA cutting ability than the former presumably due to the hydrophilic character of the amino acid glutamine.
author2 Yang ding ya
author_facet Yang ding ya
Lu ya hui
呂雅惠
author Lu ya hui
呂雅惠
spellingShingle Lu ya hui
呂雅惠
Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten
author_sort Lu ya hui
title Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten
title_short Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten
title_full Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten
title_fullStr Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten
title_full_unstemmed Design and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as potential DNA cutting agentsDesign and synthesis of DMQ-MA-based peptide derivatives as poten
title_sort design and synthesis of dmq-ma-based peptide derivatives as potential dna cutting agentsdesign and synthesis of dmq-ma-based peptide derivatives as potential dna cutting agentsdesign and synthesis of dmq-ma-based peptide derivatives as poten
publishDate 2008
url http://ndltd.ncl.edu.tw/handle/88210925915832722261
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