Apply Rapid Prototyping Technology in Tumor VesselFabrication for Investigating Thermal Ablation using HighIntensity Focused Ultrasound

• Main Authors: Yi-Syun Wu, 吳宜勳
• Other Authors: 江卓培
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/95jk45

碩士 === 國立虎尾科技大學 === 機械與機電工程研究所 === 97 === The tendency of minimally invasive surgery (MIS) is non-invasive thermal ablation surgery due to its advantages of less blood bleeding and quick recovery period. High intensity focused ultrasound (HIFU) is one of non-invasive surgery and encourage researchers to investigate its efficacy of tumor treatment. The influence of efficacy can be concluded as power, exposing duration and flowing rate of tissue fluid. In addition, the surgeons suggest that the safety treatment of HIFU is not only to thermal ablating the tumor but also to occlude the tumor vessel. This is because the tumor vessel is the pathway of nutrient supplement of tumor growth and cancer cell migration. Hence, the aims of this research is to develop an evaluation protocol for HIFU treatment parameters as described above based on rapid prototyping technique. Firstly, two molds (arbor mold and vessel shell mold) were fabricated by fused deposition modeling system (FDM). Secondly, a silicon based gel mixed with thermal sensitive powder was used to be the raw material of vessel phantom. Thirdly, thermal ablation experiment of vessel phantom was carried out by developed three-axis position system. Furthermore, the vessel model was created based on finite element analysis software (ANSYS) for simulating the influence of each parameters and comparing with experimental results. Consequently, an optimized set of treatment parameter was selected from simulation results and proved that it can occlude the vessel phantom successfully by experiment testing in case that tissue fluid was egg white (protein). The developed protocol is a promising tool for HIFU pre-clinical planning.