| Summary: | 碩士 === 國立臺灣科技大學 === 高分子系 === 97 === A novel hydrogel based on the block copolymer of polydimethylsiloxane-polyurethane (PDMS-PU) and 2-hydroxyethyl methacrylate (HEMA) was synthesized. This novel hydrogel was consisting of soft segment of poly(dimethylsiloxane) dialkanol with hydroxyethyl propoxy end groups and hard segment of isophorone diisocyanate (IPDI). Poly(ethylene glycol) methacrylate (PEGMA) was added as the chain-extender. Finally, by reacting silicone macromer (PDMS-PU) with HEMA under UV-photopolymerization, the copolymer was resulted (PDMS-PU-HEMA). The results showed that the water content of the hydrogel increased with the HEMA content. The Young’s modulus and tensile strength of the dry hydrogel also increased with HEMA content. At a HEMA content of 40%, the oxygen permeability (Dk) would remain 77% of that of the PDMS-PU. The optical transmittance of the PDMS-PU-HEMA hydrogel remained 94% of that of PDMS-PU. Furthermore, these hydrogels were non-cytotoxic through in vitro L929 fibroblasts assay. Overall results demonstrated that the PDMS-PU-HEMA hydrogel exhibited relatively high oxygen permeability, hydrophilicity, and optical transparency, therefore would be applicable as an ophthalmic material.
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