The regulatory T cell and Th17 cell in oral Squamous cell carcinoma: correlation with clinicopathological parameters

• Main Authors: Ya-Ting Chang, 張雅婷
• Other Authors: 賈景山
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/88864454670475582862

碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 97 === Oral squamous cell carcinoma(OSCC) accounts for over 90% of the oral malignant neoplasms, ranks as the sixth major cause of cancer mortality rate in Taiwan and the incidence rate is raising. In addition to mutation of oncogene and gene toxicity, the cancer immune-editing is one of the important factors in human cancer currently. We proposed that the imbalance of OSCC microenvironment affects immune regulation of cancer specific T-cell immunity. Therefore, we investigated TIL-expressing the FOXP3, a key transcription factor for regulatory T cells (Tregs); IL-17, a hallmark of Th17 cells and B7-H1, an inhibitory molecule in human oral squamous cell carcinoma and their correlation with patients’clinicopathological parameters, by immunohistochemistry staining in 38 OSCC patients. The results revealed that the expression of FOXP3+ Tregs, IL-17+ TIL, and B7-H1+ TIL was significantly associated with tumor size ( p =0.028, 0.037, 0.043, respectively) or pathological stage (p=0.001, 0.030, 0.002, respectively). The linear correction analysis and ANOVA test indicated that FOXP3+ Tregs and IL-17+ TIL were positively correlated (statistically significant, p < 0.0001) and that positive correction was also found between FOXP3+ Tregs and B7-H1+ TIL (statistically significant, p< 0.0001). Furthermore, we also observe the expression of IL-17 or B7-H1 molecules on FOXP3+ Tregs in the tumor microenvironment. Therefore, FOXP3+ Tregs , IL-17+ TIL and B7-H1+ TIL were associated with poor prognostic factors. Consequently, TIL-expressing the FOXP3, IL-17 and B7-H1 may play an important role in the tumor pathogenesis of oral squamous cell carcinoma.