| Summary: | 碩士 === 臺灣大學 === 醫學工程學研究所 === 97 === Conventional electrical stimulation used hundreds of hertz and special form of pulse to interfere with signal of nerve, and advanced technology was developing on implantable device, can stimulate directly on central nervous system and reduce intensity of pain, but this kind of stimulation need frequently use, and will cause impedance of electrode increase、nervous pathological changes after long-term stimulation、effect of release pain decrease and other phenomenon. Pulsed-radiofrequency stimulation(PRF) is one of main Interventional pain management (IVPM), using PRF stimulate the neurons on nervous pathway to block pain。In clinical application, one stimulation can maintain release pain for 3-6 months，but the mechanisms of conventional and PRF are different, conventional stimulation is interference, and PRF is block, so far the recent studies reported the mechanism of pain pathway and pain control by PRF is not clear，The present study is aimed at design of parameters of PRF stimulation for implantable device, and verification of feasibility and security of implantation。We designed PRF parameters, ±5 volts,500-KHz RF pulses, 25 milliseconds in duration. The pulses were delivered at 2Hz for a period of 5 minutes, to stimulate rat of pain model，The rats were randomly divided into two group：Control group and PRF group，PRF group were stimulated about mentioned parameter after spinal nerve ligation (SNL)，and Control group received same procedure as PRF group without PRF stimulation after SNL. von Frey behavior test was performed in both groups then. We observed the behavior change of 3rd、5th and 8th days after surgery, to verify the efficacy of PRF with the parameter we use . The Control group could tolerate the force of 3.72g at 3rd day after surgery, but PRF group could tolerate the force of 9.10g; which is significantly different ( P values <0.001). It proved the efficacy of PRF on pain control under the parameters we designed, whereby low power、local current through bi-polar electrode applied
This research can prove the parameter of stimulation : bio-polar electrode、Low power(+5 ~ -5 volt)、local current，compare with clinical parameter：mono-polar electrode with pad、high power(45volt)， experimental parameter had effect of pain release，because electrode is bipolar type，current only flow between two tips of bipolar electrode，there is no risk that pad fall from skin during stimulation，furthermore application of PRF on DRG with experimental parameter can release pain on spinal nerve ligation (SNL) model of neuropathic pain model of rat, the effect can maintain at least 3days.
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