Study on the Effect of O2-Plasma Treatment on Surface Characteristics of Bio-medical Ti-Nb Based Alloys

• Main Authors: En-Yu Wu, 吳恩育
• Other Authors: Yung-Ning Pan
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/44543788792935031412

博士 === 國立臺灣大學 === 機械工程學研究所 === 97 === This study employed low temperature plasma treatment to modify the surfaces of Ti-Nb based alloy. Firstly, argon plasma treatment is used to clean the contamination and impurity on the alloy surface, and then oxygen plasma treatment was performed to induce the formation of the oxide layer on the alloy surface. Scanning electron microscopy (SEM), grazing incident X-ray diffraction (GIXRD) and electron spectroscopy for chemical analysis (XPS) were employed to analyze the characteristics of the oxide layer formed by plasma treatment. The thickness and wettability of oxide layers on the surface of the titanium alloy were measured by secondary ion mass spectrometer (SIMS) and contact angle, respectively. In vitro study, the compatibility was evaluated by the parameter of cell culture, albumin adsorption and blood culture. The results show that the oxide layer was formed by oxygen plasma treatment and the main compositions are TiO2 and Nb2O5. Both the thickness and surface wettability of oxide layers increase with increasing plasma power. The results show that the oxidation effect on the alloy surface brought about by O2-plasma treatment enhances the proliferation and spreading of cells. The treated surfaces had been found to improve the clotting time and to introduce the formation of a more extensive and three dimensionally complex fibrin clots. In addition, the formation of nitrides by allylamine plasma treatment provides amino-group linkings for the attachment of albumin. In addition, after O2-plasma treatment, some specimens were further processed by allylamine plasma treatment and crosslinking with glutaraldehyde, which exhibited increased protein adsorption. Ti-Nb alloy with O2-plasma and allylamine plasma treatment is believed to attain better ability of cells and tissue healing and therefore promote osseointergration.