| Summary: | 碩士 === 國立臺灣大學 === 臨床動物醫學研究所 === 97 === Fifty-one naturally infected feline infectious peritonitis (FIP) diseased cats were enrolled in this study for staging of the course of FIP disease. Effusive FIP was found in 30/51 cats (58.8%), whereas non-effusive FIP was diagnosed in 12/51 cats (23.5%), and nine cats (9/51, 17.6%) were mixed type. The age ranged from 3 month-old to 7 year-old. Most of them were less than 1-year-old (38/51, 74.5%). Twenty-five of 51 (49%) cats with FIP were male while 26 (51%) were female. There was no gender prevalence. Anorexia (55.6~75%), fever (50~77.8%), and depression (33.3~60%) were the major clinical signs at presenting. Higher detection rate of coronavirus by RT-PCR was found in pleural effusion (9/9, 100%), ascites (17/18, 94.4%), and rectal swabs (66.7% in non-effusive FIP, 60% in effusive FIP). The clinicopathological changes include anemia, lymphopenia, hyperbilirubinemia, hypoalbuminemia, hyperproteinemia, elevation of ALT and AST, hyponatremia, and hypokalemia. Highly significant (p<0.01) decreasing of hematocrit (26.5±7.0% to 17.0±4.6%), elevation of total bilirubin (0.7±1.0 mg/dL to 2.5±1.3 mg/dL), and decreasing of albumin (2.5±0.3 g/dL to 2.2±0.4 g/dL) were noted in both effusive and non-effusive FIP at presenting and 0-3 days before death. Meanwhile, significant (p<0.05) decreasing of total protein (8.1±1.4 g/dL to 7.3±1.7 g/dL), elevation of ALT (61±69 U/L to 160±177 U/L) and AST(170±215 U/L to 562±348 U/L) were also observed. In the serial blood examinations in effusive group, variation of anemia (25.8±6.3% to 17.2±4.3%, p<0.01), increasing of total bilrubin (0.5±0.4 mg/dL to 2.8±1.2 mg/dL, p<0.01) and AST (103±63 U/L to 673±322 U/L, p<0.01) were observed between 2 weeks and 0 to 3 days before death. Total bilirubin (1.0±0.9 mg/dL to 2.8±1.2 mg/dL, p<0.01) and AST (141±48 U/L to 673±322 U/L, p<0.01) increased dramatically between 1 week and 0 to 3 days before death. The correlation coefficients were 0.45557 (P=0.0017) between TP and survival time after diagnosis and 0.42981 (P=0.0032) between globulin and survival time after diagnosis. Patients with higher TP and globulin at presenting could be survival longer. In conclusion, clinicopathological finding could provide an objective evaluation in the course of disease. The change of hematocrit, bilirubin and AST were more precise to forecast the course of FIP.
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