| Summary: | 碩士 === 國立臺灣海洋大學 === 食品科學系 === 97 === The aims of this study are to investigate the effects of black soy bean or azuki bean infusion on glucose and lipid metabolism in streptozotocin–nicotinamide induced diabetic rats. Forty male Sprague -Dawley (SD) rats were randomly divided into four groups, rats drink water (normal), diabetic rats drink water (DM), diabetic rats drink black soybean infusion (DM + BI), diabetic rats drink azuki bean infusion (DM + AI) for 11 weeks. The results demonstrated that both DM + AI and DM + BI groups could lower the level of glucose, triglyceride and total cholesterol in plasma. In the aspect of carbonhydrate metabolism, DM + AI group could improve glucose tolerance at foruth week and DM + BI group showed the same effect at ninth week. To investigate glucose related metabolism enzyme in liver, hexokinase activity of DM + BI group would be reduced and the glucose-6-phosphatase activity of DM + AI group would be increased. Besides, the DM + AI group could reduce the activity of intestinal lactase and maltase. In the aspect of lipid metabolism, both DM + AI and DM + BI groups could decrease the level of VLDL + LDL- Cholesterol in plasma. Furthermore, DM + BI group also reduced free fatty acid level. On the other hand, DM + AI could decrease the value of TBARS in liver and DM + BI group could decrease the value of TBARS in plasma. In the aspect of oxidative stress, DM + BI group could increase activity of glucose-6-phosphate dehydrogenase, glutathione peroxidase and the GSH/GSSG ratio. According to above- mentioned results, both black soybean and azuki bean infusion had potency to regulate glucose and lipid metabolism in diabetic rats.
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