The Mechanisms of HDAC Inhibitor-mediated G2/M Arrest:The Crosstalk between HDAC and MAPK-ERK pathway
碩士 === 國防醫學院 === 生物及解剖學研究所 === 97 === Histone deacetylases (HDAC) are responsible for deacetylating histones and non-histone proteins, regulating gene transcription, protein function and stability. Aberrant expression and increased activity of HDACs are observed in many cancer types. Therefore histo...
Main Authors: | Lai, Xiang ME, 賴享玫 |
---|---|
Other Authors: | Sun, Guang Huan |
Format: | Others |
Language: | zh-TW |
Published: |
2009
|
Online Access: | http://ndltd.ncl.edu.tw/handle/07546723532029853170 |
Similar Items
-
The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation.
by: Mei-Jen Chuang, et al.
Published: (2013-01-01) -
Histone Deacetylase Inhibitor Induces ERK Activation through Deregulation of HDAC6 and Protein Phosphatase
by: Hsiao-Chu Lai, et al.
Published: (2010) -
Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors
by: Elizabeth A. Thomas
Published: (2014-05-01) -
Involvement of ERK activation in human osteosarcoma cell resistance to the HDAC inhibitor FK228
by: Matsubara, Hiroshi
Published: (2010) -
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
by: Haiqun Jia, et al.
Published: (2012-05-01)