| Summary: | 碩士 === 國防醫學院 === 公共衛生學研究所 === 97 === Objective. Osteoarthritis (OA) is a major public health problem due to its high prevalence, costs and levels of pain and disability. Inflammatory processes and genetic factors have been suggested to be involved in the pathogenesis of OA. Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Variations in TLR genes have been shown to be associated with various infectious and inflammatory diseases. We investigated the association of TLR-2 (G2408A), TLR-4 (A12874G and C13174T) and TLR-9 (-T1237C, -T1486C and A1635G) single nucleotide polymorphisms (SNP) with OA in Taiwanese subjects.
Methods. We performed a case-control association study and genotyped 113 Taiwanese with OA and 216 Taiwanese healthy controls analyzed by real-time PCR assays.
Results. We could not detect any significant difference in the allele frequencies of polymorphisms in the TLR-2 G2408A (In case and control, they have the same genotype), TLR-4 (A12874G and C13174T, OR=0.34-3.59, 0.35-5.67) and TLR-9 (A1635G, OR=0.56-2.93). This TLR-9 (T-1237C and T-1486C) TC genotype association was significant between OA and Healthy control (OR=0.03-0.37, 0.16-0.43 )
Conclusion. We conclude that in OA a functional TLR-9 is protective and potentially involved in a reaction pattern preventing OA. Screening for the TLR-9, T-1486C SNP may be of importance for patient’s risk and for preventive and therapeutic measures.
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