An investigation into the high shear wet granulation behaviours and the regime map development

• Main Authors: Wei-Da Tu, 杜威達
• Other Authors: Shu-San Hsiau
• Format: Others
• Language: en_US
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/q6u6p4

博士 === 國立中央大學 === 機械工程研究所 === 97 === This thesis investigated the interactions between materials properties and operating conditions in high shear wet granulation. It was found that particles sizes between 1.5 to 85 μm had a significant effect on the granule size growth rate, final average size of granules and the distribution of granule size. The liquid-to-solid (L/S) ratio had a significant effect on the growth rate as well. It was possibly because more binder addition could result in better deformability, which is essential for colliding granules to be adhered onto each other permanently. The effect of L/S on agglomeration depended on the magnitude of impeller speed, and the relationship of each other is not linear. This thesis also proposed a more clarified definition to allocate the accurate boundaries between steady growth, induction behaviour and the rapid growth on the growth regime map. This can enable a better prediction of granulation behaviours. A growth regime map for this thesis was drawn. This map showed that a single system of solid and binder can exhibit five growth behaviours. A pre-requisite of monomodal GSD (granule size distribution) was found the same with that in a rotating drum [1]. Several suggested experiments regarding its microscopic description and other possible investigation plans were proposed in Chapter 5.