| Summary: | 碩士 === 國立成功大學 === 分子醫學研究所 === 97 === Helicobacter pylori exploit blood group antigen-binding adhesin (BabA) to interact with Lewis b to establish persistent colonization on gastric epithelium cell. Previous studies have shown that babA can be replaced by babB, an uncharacterized outer membrane protein that is closely related to babA. Many different genotypes are found in the clinical strains and associated with different adhesion ability. Whether different genotypes of H. pylori are related to the clinical outcome remains to be answered. The aims of my project were to understand the gene profiles of babA and babB presented in our clinical strains, the correlation between gene profiles and gastric disease. A total of 109 strains collected from NCKU hospital were used to analyze different gene profiles were analyzed by PCR. The A B gene profile (39/109，35.8%) was more dominant than other gene profiles, AB B (34/109，31.2%), AB AB (31/109，28.4%), A AB (5/109，4.6%). The AB AB gene profile type is specific type in Taiwan, and correlation with gastric cancer (p = 0.01). The correlation between AB AB gene profile type and gastric cancer was gone through acute inflammatory (P ≦ 0.05) not through different Leb binding activity and precancerous changes.
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