| Summary: | 碩士 === 國立中興大學 === 獸醫學系暨研究所 === 97 === Abstract
Mitral valve disease (MVD) is the most common acquired cardiac disease in dogs. Pimobendan (PIMO) and ACE inhibitor (ACEi) are frequently used for congestive heart failure. The aim of the study was to monitor the changes of the cardiac function, dimensions of the cardiac silhouette in thoracic radiograms, degree of pulmonary edema and hemodynamic effects in dogs with mitral valve regurgitation (MR) after the treatment of PIMO, enalapril, and combined use of two drugs. Eighteen dogs with mild-moderate MR and six healthy dogs were recruited in this study. The dogs with MR were randomly allocated into 3 groups and monitored at the day 0, 7, 28 and 56. Doppler echocardiography showed that the MR velocity had increasing tendency in the PIMO group (p<0.05). Haematology and blood biochemistry revealed creatinine and potassium concentration had increasing tendency in the enalapril group (p<0.05). The degree of pulmonary edema had decreasing tendency in the combined group (p<0.05). However, the velocity of mitral and the aorta valve measured from the dogs with MR were higher than that from the healthy dogs (p<0.05). Above results indicates that PIMO increase mitral valve regurgitation in the dogs with heart failure. The combined use of PIMO and enalapril may decrease the adverse effect of PIMO and comfort the pulmonary edema severity. Additional studies are required to investigate the adverse effect on blood pressure and changes of mitral valve regurgitation in different dose response.
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