| Summary: | 碩士 === 國立中興大學 === 獸醫學系暨研究所 === 97 === In 1991, it was first reported that obesity in feline was associated with neutering. Increased food intake and decreased metabolic rate after neutering might be the reason leading to obesity. Obesity will lead to insulin resistance and impaired glucose tolerance in human and feline. Type 2 diabetes mellitus (non-insulin dependent diabetes mellitus) is preceded by insulin resistance and impaired glucose tolerance. The aim of this study is to investigate the relationship between neutralization and diabetes mellitus in female cats. In our study, four 3-year-old female neutered cats were enrolled into this observation. Body weight of cats was measured every day. Intravenous glucose tolerance test was performed at 1, 2, 3, 4 and 5 months after neutering. Blood samples were collected at 0 and 10, 20, 30, 60 and 120 minutes from intravenous catheter after glucose administration. Plasma insulin and glucose were measured by Mercodia Feline Insluin ELISA and ACCU-CHECK® Active, respectively.In the results, body weight and BMI of cats were significantly higher at 2, 3, 4 and 5 months after neutering in comparison to the time after neutering (p<0.05). The weight gain in 4 cats was 36%, 36%, 59% and 25% respectively. The area under curve of plasma glucose was lower in cat no.4 at 5 and 6 months after neutering in comparison to other cats. The results of fasting insulin and HOMA fluctuated in 6 months observation.In our study, ovariohysterectomy leads to increased body weight and BMI. Overweight in female cats is associated impaired glucose tolerance. Insulin resistance is not found in this study. We suggest that glucose intolerance precedes insulin resistance in the early stage of obesity. Because of the variation of insulin secretion in feline is wide, increase in sample size is necessary in future study.
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