Mixed micelle composed of thermo-sensitive and biodegradable copolymers for drug delivery and magnetic resonance imaging (MRI) applications

• Main Authors: Yung-Wei Chang, 張永威
• Other Authors: 廖明淵
• Format: Others
• Language: en_US
• Online Access: http://ndltd.ncl.edu.tw/handle/87927755223179509041

碩士 === 國立中興大學 === 化學系所 === 97 === Multifunctional micelle is emerging as a highly integrated platform that allow for molecular diagnosis, targeted drug delivery, and simultaneous monitoring and treatment of cancer. Biodegradable and thermal-sensitive mixed micelles are composed of poly(L-lactide)-poly(ethylene glycol) (PLA-PEG) and Pluronic F127 (PF127) were developed for controlled drug delivery. Free doxorubicin and superparamagnetic iron oxides (SPIO) were encapsulated in the mixed micelles for sustained DOX release and magnetic resonance imaging (MRI). The mixed micelles can generate heat by applying an alternating magnetic field (AMF), as the temperature increased that result in the significant release of DOX, and the MRI contrast agents have a strong effect on T2 relaxation. These findings demonstrate that the mixed micelles containing chemotherapeutic agents and SPIO could be a multifunctional nanocarrier for cancer treatment and imaging. The novel mix types of micelles are composed of some key components: (1) a chemotherapeutic agent doxorubicin (DOX) that is released from polymeric micelles. (2) superparamagnetic iron oxide (SPIO) nanoparticles is loaded inside the micelles for MRI detection. (3) because of the magnetic properties, the mixed micelles can generate heat AFM. (4) based on the characteristics of polymers, the temperature controlled system can controlled the drug release.