A Two-Dimensional Mathematical Model Simulating Intracellular Diffusion Quantifies Contributions of Steric Hindrance and Binding Effect
碩士 === 國立中興大學 === 化學工程學系所 === 97 === Intracellular mass transport plays as critical role in biological function, a variety of genetic diseases are related to the mal function of intracellular transport. Previous research on quantification of cytoplasmic diffusion coefficient has isolated the binding...
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| Format: | Others |
| Language: | zh-TW |
| Online Access: | http://ndltd.ncl.edu.tw/handle/64615808954050433817 |
| Summary: | 碩士 === 國立中興大學 === 化學工程學系所 === 97 === Intracellular mass transport plays as critical role in biological function, a variety of genetic diseases are related to the mal function of intracellular transport. Previous research on quantification of cytoplasmic diffusion coefficient has isolated the binding effect as one of the factor in determination of apparent diffusion coefficient. This research further isolated steric hindrance from factor such a viscosity and binding .Contribution of retarder from diffusion obstacle such as cytoskeleton and organelles are calculated and quantified. Results of the mathematical model are compared with experimental data from literature and satisfactory agreements are obtained.
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