Study on the ultrasonically-activated permeability of CHC

• Main Authors: Hsiao-Che Fan, 范曉哲
• Other Authors: Yang-Yen Yu
• Format: Others
• Language: zh-TW
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/91487616769942756362

碩士 === 明志科技大學 === 化工與材料工程研究所 === 98 === Carboxymethyl-hexanoyl chitosan (CHC) and chitosan (CS) membranes were prepared for characterizing their ultrasonically-activated permeabilities. Four bioactive agents with differing hydrophilicity, molecular weight and electric charge were employed as model drugs to investigate the mechanism of the ultrasonically-activated permeability of CHC. It was found that methylene blue (positive charge) demonstrated the highest ultrasonically-activated permeability while it permeated through the CHC membrane (minor positive charge) under sonication. However, methyl orange (negative charge) demonstrated its ultrasonically-actived property in the CS membrane (positive charge). In addition, vitamin B12 also demonstrated medium ultrasonically-activated properties in the CS and CHC membranes. This suggests that the ultrasound-sensitive characteristic of the CHC membrane was significantly affected by the electric charge and molecular weight of bioactive agents. In addition, the model drugs with different properties (electric charge) and with opposite electrical properties of membranes (CS and Alginate) permeability experiments to study the electrical properties of ultrasound at different model drug interaction with membrane and its mechanism. The results showed that: both the positively charged methylene blue or negatively charged methyl orange and with opposite electrical substrate for permeabilities, ultrasound-sensitive are showing the opposite trend. Positively charged methylene blue and the negatively charged groups of alginate in the ultrasound characteristics of the less sensitive to the positively charged CS is more significant; negatively charged methyl orange were positively charged CS with better ultrasound sensitivity. The negatively charged alginate because of the characteristics have made the positively charged methylene blue penetration in the more negatively charged adsorption of methyl orange is more obvious; In addition, the positively charged CS and thus also have the opposite trend. Finally, alginate microspheres pattern to the performance and conduct of drug loaded microspheres release of the performance of such experiments in order to complete the release of the phenomenon of drug carrier. This study is the use of different substrate conditions and drug each other, with the ultrasonic effect, the establishment of amphiphilic polymers as ultrasound-sensitive drug carrier design.