Synthesis of Azaisoflavone Derivatives
碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 97 === Synthesis and evaluation of azaisoflavone derivatives are described. The synthesis of the main structure is accomplished by using different anilines and β-keto esters in the condensation reaction and Conral-Limpach reaction. We have obtained a number of azaiso...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2009
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/50674342328224659963 |
| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 97 === Synthesis and evaluation of azaisoflavone derivatives are described. The synthesis of the main structure is accomplished by using different anilines and β-keto esters in the condensation reaction and Conral-Limpach reaction. We have obtained a number of azaisoflavones substituted with different functional groups for biological evaluations with our aims to investigate structural features with respect to the biological properties and to establish structure-activity relationships (SAR). We expect azaisoflavones can be better than isoflavone compounds in the pharmacological activity and selectivity.
Preliminary assays indicated that these compounds were non-cytotoxic against three cancer cells including MCF-7(breast cancer), NCI-H460 (lung cancer) and SF-286 (CNS cancer). Thus, these azaisoflavone derivatives will be evaluated for their anti-osteoporotic activity in the future.
|
|---|