Studies on the Benzo[f]indole-4,9-dione Derivatives

• Main Authors: You-Ren Chen, 陳宥任
• Other Authors: Cherng-Chyi Tzeng
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/97141688364732054034

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 97 === This study confers mainly how to synthesize the feature of benzo[f]indole-4,9-dione dervatives with the structure of planar tricyclic ring. We can confer the series of compounds whether they have the activity of anti-cancer and anti-bacterial by way of modifying the C-4 carbonyl group and the N-1 position. The primitive result of indicated that 1-vinyl-1H-benzo[f]indole-4,9-dione (22q) shows the most potent activity of anti-cancer. When the C-4 position of the ring was derivatized with alkoxyimino or procainamido group, the activity of anti-cancer was enhanced. The result of anti-bacteria evaluation shows that 4-(4-(dimethylamino)- butoxyimino)-1-phenethyl-1H-benzo[f]indol-9(4H)-one (34g) possesses an obvious effect for inhibit the production of biofilm.