Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs

Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs

碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所碩士在職專班 === 97 === We use the coupling reaction of Pd to form a diaryl acetylene, generated diaryl acetylene, adding NaN3, the use of synthetic triazole ring of addition reaction, developed by microwave digestion method, to establishment appropriate microwave temperature a...

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Main Authors: Yi-Lien Weng, 翁溢蓮
Other Authors: Shinne-Ren Lin
Format: Others
Language:zh-TW
Published: 2009
Online Access:http://ndltd.ncl.edu.tw/handle/89002234396082593926
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spelling ndltd-TW-097KMC055370062016-05-09T04:13:52Z http://ndltd.ncl.edu.tw/handle/89002234396082593926 Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs CombretastatinA-4之1,2,3–三唑類似物的合成與生物活性 Yi-Lien Weng 翁溢蓮 碩士 高雄醫學大學 醫藥暨應用化學研究所碩士在職專班 97 We use the coupling reaction of Pd to form a diaryl acetylene, generated diaryl acetylene, adding NaN3, the use of synthetic triazole ring of addition reaction, developed by microwave digestion method, to establishment appropriate microwave temperature and solvent, synthesis a series of Combretastatin A-4 1,2,3 - triazolo analogues (31a - f ), the yield is 30% to 86%, by cell cycle of human leukemia K-562 tumor cell line to evaluate its biological activity. Shinne-Ren Lin 林信人 2009 學位論文 ; thesis 91 zh-TW
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language zh-TW
format Others
sources NDLTD
description 碩士 === 高雄醫學大學 === 醫藥暨應用化學研究所碩士在職專班 === 97 === We use the coupling reaction of Pd to form a diaryl acetylene, generated diaryl acetylene, adding NaN3, the use of synthetic triazole ring of addition reaction, developed by microwave digestion method, to establishment appropriate microwave temperature and solvent, synthesis a series of Combretastatin A-4 1,2,3 - triazolo analogues (31a - f ), the yield is 30% to 86%, by cell cycle of human leukemia K-562 tumor cell line to evaluate its biological activity.
author2 Shinne-Ren Lin
author_facet Shinne-Ren Lin
Yi-Lien Weng
翁溢蓮
author Yi-Lien Weng
翁溢蓮
spellingShingle Yi-Lien Weng
翁溢蓮
Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs
author_sort Yi-Lien Weng
title Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs
title_short Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs
title_full Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs
title_fullStr Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs
title_full_unstemmed Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs
title_sort synthesis and biological activity of combretastatin a-4 1,2,3-triazole analogs
publishDate 2009
url http://ndltd.ncl.edu.tw/handle/89002234396082593926
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AT wēngyìlián combretastatina4zhī123sānzuòlèishìwùdehéchéngyǔshēngwùhuóxìng
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