Differences of proteolytic enzymes in permissive and non-permissive hosts for Angiostrongylus cantonensis infection

• Main Authors: Shu-Chi Yang, 楊恕奇
• Other Authors: Min-Yuan Hung; Tai-An Chiang
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/50558853764909363204

碩士 === 中華醫事科技大學 === 生物科技研究所 === 97 === Angiostrongylus cantonensis is a neurotrophic and pulmonary parasite which normally lives in the pulmonary artery of permissive hosts (rats), which is widely distributed in tropical and subtropical areas where rodents (the natural and definitive host) are known to be infected with this parasite. The distribution of mainly in South East Asia and the South Pacific, especially in Taiwan, can be found genarally. The parasite infection can cause the eosinophilic meningitis and eosinophilic meningoencephalitis when non-permissive hosts (such as mice, guinea pigs, rabbits, rhesus monkeys, and humans etc...). In this study results showed that there is a significant correlation between plasminogen activators (PAs) and matrix metalloproteinase-9 (MMP-9) in the non-permissive model. The data also indicated that proteolytic enzymes such as PAs and MMP-9 certainly had differences in both the permissive and non-permissive models. These differences suggested the relation between the occurrence of eosinophilic meningitis and eosinophilic meningoencephalitis and the infection of Angiostrongylus cantonensis in a non-permissive host.