| Summary: | 碩士 === 中山醫學大學 === 醫學研究所 === 97 === Anti-inflammatories and analgesics are ubiquitous in the modern medical world. There has been a variety of studies into such medicines.
The aim of this study is to compare the effects of traditional Chinese medicines including Corydalis Rhizoma and Shao-Yau-Kan-Tsao-Tang, and Western medicines such as Aspirin and Nimesulide. The focus will be on their anti-inflammatory and analgesic benefits.
This experiment will commence by observing the behaviour of rats in Hall’s Open Field after the administration of the medicines. Secondly, the pain-killing benefits of the medicines will be ascertained by using 0.7% Acetic Acid on visceral smooth muscle. Then Carrageenin will be used to induce Edema in the rats, thus allowing the comparative anti-inflammatory and analgesic benefits of the medicines to be ascertained. Lastly, a study of the effects on the cells of the swollen tissue will be undertaken by analysing pathological and histological slides under the microscope. The effects on the liver and kidney due to the taking of the medicine will also be determined.
According to the results of this research, it has been determined that the traditional Chinese medicine Shao-Yau-Kan-Tsao-Tang is the most effective in terms of providing analgesia to visceral pain when cramp occurs in internal organs (p<0.01) than the other three medicines tested. For the swelling on the experimental animals’ toes, traditional Chinese medicine Corydalis Rhizoma has a greater ability to provide an anti-inflammatory effect (P<0.01). As for Nimesulide, which has a selective COX-2 inhibition effect, it appears to have had no significant benefit on the pain of visceral smooth muscle.
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