| Summary: | 博士 === 中山醫學大學 === 醫學研究所 === 97 === Human nonmetastatic clone 23 (nm23-H1) and human telomerase reverse
transcriptase (hTERT) may be separately involved in tumor progression of
uterine cervix. Moreover, we found normal cervix and cervical low-grade
intraepithelial neoplsia (low-grade CIN) samples had concurrent low expression
of hTERT and nm23-H1, whereas high-grade CIN [CIN2 (moderate dysplasia)
and CIN3 (severe dysplasia, carcinoma in situ)] SCC samples had concurrent
high immunoreactivity. However, hTERT immunoreactivity seemed to have no
significant association with clinicopathological variables of cervical cancer. On
the contrary, only deep stromal invasion was significantly associated with high
nm23-H1 immunoreactivity based on our limited cervical tissue samples. A high
cumulative recurrence hazard was demonstrated for the high nm23-H1
expression group. Therefore, using real time polymerase chain reaction and
tissue microarray of cervical samples, we further demonstrated that nm23-H1
mRNA expression and H score (median H scores: 2.0 vs. 0.3, P = 0.001) were
higher in cervical cancer tissues than normal counterparts, respectively.
Nm23-H1 expression was significantly associated with depth of stromal
invasion (P = 0.003), tumor diameter (P = 0.044) and cell differentiation (P =
0.025). Furthermore, positive nm23-H1 expression was significantly associated
with poor overall survival.
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