The preventive effect of Solanum nigrum water extract in aspirin-induced rat gastric mucosa damage

• Main Authors: Yu-Feng, 洪玉鳳
• Other Authors: 李彗禎
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/20357579070432812988

碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 97 === A recent study demonstrated that long-term use of aspirin, a none-steroidal anti-inflammatory drug (NSAID), will cause gastric mucosal damage, gastro-duodenal ulcers and complication. The cause could be due to aspirin induced reactive oxygen species (ROS) and decreased gastric mucosal antioxidant activity. We previously showed Solanum nigrum water extract (SNE) possessed antioxidative activities. In this study, we tried to detect the protective effect of SNE in aspirin inducing gastric mucosal damage. Animals were pretreated with SNE (100 mg/kg, 200 mg/kg, 400 mg/kg) for 1 hour, and then 200 mg/kg of aspirin was oral-fed to induce gastric mucosal lesions. After 4 hours, the animals were sacrificed to perform the following detections. We observed that SNE can reduce the white blood cell and the contents of malondialdehyde (MDA) in the gastric mucosa. SNE can also recover antioxidant enzyme activities such as total GST, GST Ai, GST Pi and GSH which were decreased by aspirin. In conclusion, SNE protects aspirin-induced gastric mucosal damage could be via regulating anti-oxidative enzyme activities and reducing the damage of ROS.