| Summary: | 碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 97 === Coronary heart disease (CHD) is one of the predominant causes of disease-related death and disability in all industrialized countries. Heart disease was the second leading death in Taiwan in 2004. Acute myocardial infarction (AMI) is a major CHD in Taiwan. Among risk factors identified by epidemiological studies, smoking, hypertension, and diabetes mellitus are considered the most important predictors for the risk of AMI at the individual level.
Oxidative stress, which is due to primarily imbalance between reactive oxygen sprcies (ROS) and antioxidants in favor of the former, has been a focus of research for many years. Copper-zinc superoxide dismutase (SOD1) is widely distributed and comprises 90% of the total superoxide dismutase (SOD), catalyzes the conversion of superoxide to hydrogen peroxide. The aim of this study was to examine whether polymorphism of SOD1 gene is association with the risk of AMI. We have performed a case-control study from 65patients. SOD1 gene polymorphism was determined by analyzing HhaI-digested DNA fragment obtained by PCR. An association of the SOD1 C/A genetype of control to the AMI onset was not found. In conclusion, our result suggested that SOD1 polymorphism was not associated with AMI among Taiwan with convestional cardiovascular disease risk factor.
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