The association of catalase polymorphism and acute myocardial infarction

• Main Authors: Yi-May, 蔡懿玫
• Other Authors: 許立松
• Format: Others
• Language: zh-TW
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/67817025736316353758

碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 97 === Recently many studies have revealed that vascular inflammation plays an important role in the development of acute myocardial infarction (AMI). The infiltration and retention of low-density lipoprotein （LDL）in the arterial intima initiate an inflammatory response in the artery wall. Oxidised low-density lipoprotein(LDLox) have been reported to mediate enhanced superoxide formation . LDLox-mediated formation of reactive oxygen species （ROS）also causes plaque formation.These effects can be prevented by treatment with superoxide dismutases（SOD）and catalase. The SOD, which convert superoxide anion into hydrogen peroxide, catalase, whereas reduces hydrogen peroxide to water. The aim of the study was to examine whether polymorphism of the catalase gene is associated with the risk of AMI. Therefore, we performed a case-control study from 117patients. The study population comprised of 28 AMI patients,51 healthy individuals without AMI disease history (IIA), and 38 personnel don’t have any conventional cardiovascular disease risk factors (IIB). Catalase gene polymorphism was performed by analyzing Hinf1-digested DNA fragment obtained by polymerase chain reaction (PCR).The –21A/T polymorphism frequency of catalase gene was similar in patients and the controls. No association of –21A/T polymorphism was detected in comparisons with control IIA、control IIB and total control .In conclusion, the catalase gene does not appear to be a susceptibility locus for acute myocardial infarction.