| Summary: | 碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 97 === Fatty liver is a kind of triglyceride metabolic disorder that makes the liver cells accumulate excessive lipid particles. This may cause liver-related disease. Caffeic acid（3,4-dihydroxycinnamic acid or CA）is distributed in vegetables, red wine, fruits, whole grains﹐ honey and other substances. Ac-cording to the research literature
﹐phenolic compounds like caffeic acid has antioxidants and atte-nuates plasma lipids, so offering a medical protective function. In this experiment two groups of mice were fed a high fat diet（HFD）； the second groups given the high fat diet also contained a mixture of 0.02%, 0.08% caffeic acid, Six weeks later the mice fed only a high fat diet were found to have an increase in AST, ALT, TG, Cholersterol, Glucose while the HDL-C is decreased in value . The group given the high fat diet with caffeic acid were found to have a decrease in AST, ALT, TG, Cholersterol, Glucose while the HDL-C increased. Each week of the experiment body weight and liver weight were gauged along with liver tissue slice observation, the result being of 0.08% caffeic acid sample the color and outward appearance obtained improvement. The liver weight average reduced lipid vacuole accumulation of the tissue slice obviously improve. 0.08% caffeic acid may attenuate hepatic accumulation which high fat diet causes, reducing the liver extent of damage. Thus in the blood serum biochemistry value determination, 0.08% caffeic acid may attenuate the HFD-induced fatty liver and protect the liver.
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