| Summary: | 碩士 === 中山醫學大學 === 公共衛生學系碩士班 === 97 === Objective: The ecological study was to investigate the relationship between lung cancer incidence by histologic types and air pollution indexes in Taiwan. Methods: Air pollution index data was from 70 air quality monitoring stations in different municipalities. We calculated the average air quality values (SO2, CO, O3, NOx, NO, and NO2) from the Taiwan environmental protection association (EPA) between 1994 and 1998. Patients with lung cancer were identified through the National Cancer Registration Program operated by the Taiwanese government. Two major pathological types were adenocarcinoma (AC) and squamous cell cancer (SCC). The Spearman’s correlation coefficients were to calculate the relationship between the air quality index and age-standardized incidence rate (ASR) of AC and SCC in both genders. We conducted 4 levels of analyses based on different NO concentrations (i.e., ≤ 5.590 ppb, 5.590-8.554 ppb, 8.554-13.536 ppb, > 13.536 ppb) when adjusting for NO2, CO, SO2, and O3, used Poisson Regression to estimate the relative risk of lung cancer. Results: The traffic-related NOx and NO showed significantly positive correlations with males (0.424 v.s. 0.434) and female (0.277 v.s. 0.369) AC type incidence rates. Using NO concentration ≤5.59 ppb as the baseline, the risk for AC among males at 5.59 < NO ≤ 8.554 ppb was 1.324 times of that at the baseline level (95% CI: 1.105-1.587), 1.332 times at 8.554 < NO ≤13.536 level (95% CI: 1.106- 1.606), 1.655 times when13.536 < NO (95% CI: 1.361-2.014). The test for trend was statistically significant at p < 0.0001. Similar results were observed among females with increasing NO concentration, the risk for AC went up 1.308, 1.273, and 1.535 times of the baseline level. The test for trend was highly significant at p < 0.0001. On the contrary, the results did’nt find any relationship between NO and SCC in both males and females. Conclusions: The results showed that a dose-response relationship between NO and lung AC incidence in both genders.
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