| Summary: | 博士 === 長庚大學 === 臨床醫學研究所 === 97 === Oxidative stress has been associated with degenerative diseases such as
cardiovascular and neurodegenerative diseases. Acute myocardial infraction (AMI)
is one of the major causes of death among cardiovascular diseases. Inflammation, a
major risk factor of AMI, is associated with leukocyte activation, secretion of
myeoperoxidase (MPO) and subsequent generation of oxidants. It has been
hypothesized that oxidative stress is a risk factor for AMI. To test this hypothesis, we
studied the oxidative stress profile, including oxidative damage markers and
antioxidants in patients with AMI. Antioxidant levels, such as vitamin E and
glutathione peroxidase, in blood specimens were significantly lower in AMI patients
than those in controls. Whereas oxidative damage markers, 8-OHdG and 3-Cl-Tyr, as
well as MPO an oxidant generator, were higher in these patients. In addition,
GSH/GSSG ratio, indicative of redox status, was lower in AMI patients. These
findings suggest that AMI patients experienced with increasing oxidative stress.
Moreover, our study also suggests a panel of markers would be more effective for
evaluating antioxidant status and monitoring cardiac events than the same markers
used separately. Furthermore, a pilot study was conducted to evaluate oxidant and
antioxidant markers for patients with chest pain in the emergency room. Due to small
sample size, the oxidative stress evaluation from blood specimens collected from
emergency room had no significant statistical difference between AMI and non-AMI
patients. Therefore, a larger samples size and a more appropriate statistical method
will be needed to evaluate the clinical significance of oxidative stress in AMI.
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