In-vitro release of paclitaxel from biodegradable stent

• Main Authors: Chao Ying Hsiao, 蕭肇英
• Other Authors: S. J. Liu
• Format: Others
• Published: 2009
• Online Access: http://ndltd.ncl.edu.tw/handle/82593613069859314964

碩士 === 長庚大學 === 機械工程研究所 === 97 === The purpose of this report was to investigate the in-vitro release of paclitaxel from biodegradable poly(-caprolactone) stents. Poly(-caprolactone) stents were first manufactured by a lab-made micro-injection molding machine. Paclitaxel and PLGA were dissolved in acetonitrile and were coated onto the surface of the stents by a spray coater, which was designed and built especially for this study. An elution method was utilized to characterize the in-vitro release characteristics of the paclitaxel over a 70-day period. The HPLC analysis showed that biodegradable stents released a high concentration of paclitaxel in vitro for up to 60 days. One could prolong the total period of drug release by adopting 75:25 PLGA polymers, increasing the number of coated layers, and increasing the drug loading. The effect of eluted paclitaxel on cell behavior was studied. The results suggested that the eluted drug could effective inhibit the proliferation of smooth muscle cells. By adopting this novel technique, we will be able to fabricate biodegradable stents of various types of drugs for cardiovascular applications.