| Summary: | 碩士 === 國立中正大學 === 機械工程所 === 97 === Macromolecular material Polymethyl Methacrylate (PMMA) has good nature in light transmission, bio-compatibility, chemical resistance, and mechanical strength. With its simple and cost-efficient production procedure, it is a very suitable for various material of bio-medical and chemical examination instruments. In this study, we tried to grow three self-assembled monolayers OTS, ODS, and HDT, with bio-compatibility, in the microchannel made of PMMA, in order to reduce time expense and increase examination accuracy of bio-microchannel chips. Findings of research were: in the contact angle experiment of three self-assembled layers, OTS illustrated the maximum contact angle 123° 24 hours after its reaction, while ODS and HDT showed 94° and 65° respectively. Through analysis by Fourier-Transform Infrared Spectrometer, we found that all the three self-assembled layers reached their maximum contact angles, which were caused by the increase of their terminal functionality CH3, indicating that self-assembled layers had better adhesion quality than the surface of its precursor PMMA. As experiment of static contact angle could not completely illustrate the flow ability of liquid which is to be examined, we suggested replacing the normal contact angle with dynamic inclination angle parameters as measurement indicator. The experiment showed that results of dynamic inclination angle parameters were inconsistent with those of contact angle, but more consistent with ability trend of friction coefficient. In the biotic experiment of protein concentration, OTS self-assembled film, after 24 hours reaction time, also showed the lowest protein residue. Therefore, more portion of the specimen could be maintained in the area of chip reaction and increased accuracy of test.
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