| Summary: | 碩士 === 大同大學 === 化學工程學系(所) === 96 === This thesis consists of three parts.The first part deals with A series of temperature sensitive and biodegrabable hydrogels porous
hydrogels, this series gels were preparedby copolymerizing.
N-isopropylacrylamide (NIPAAm), and the PLGA-PEG-PLGA its triblock
diacrylate polymers which as the crosslinker were synthesized by ring open
polymerization (ROP) of lactide and glycolide using poly(ethylene glycol)
and stannous octoate [Sn(Oct)2] as catalyst followed by the functionality of
acrylated group with acryloyl chloride at low temperature. The effect of
different LA/GA ratios of the NIPAAm/PELGAdA copolymeric hydrogel
on the swelling ratio and mechanical properties for the poly(NIPAAm)
hydrogels were investigated. The results showed that the swelling ratio of
the gel in deionized water increased with an increase of the content of
crosslinker segment in the NLG hydrogels and the swelling ratio increased
with an increase of the GA content in the copolymeric hydrogel. The
mechanical strength, crosslinking density, compressive modulus decrease
with an increase of crosslinker and the more LA ratio in the copolymeric
hydrogel. The results showed that the critical gel transition temperatures
(CGTT) of the gels crosslinked with PELGAdA were lower than those of the
gels crosslinked with NMBA due to the hydrophobicity of the PLGA
segment. The results also showed that the gels crosslinked with PLGAdA
had higher mechanical strength and crosslinking density than gels
crosslinked with NMBA. The gels showed good temperature sensitive and
biodegradable behavior.
The second part of this thesis describes A series of biodegradable porous hydrogels, based on biocompatible
2-hydroxyethyl methacrylate (HEMA) and a crosslinker of ABA type
amphiphilic triblock copolymers were synthesized by the condensation of
hydrophobic polycaprolactone diol (PCL diol) with hydrophilic dicarboxy
poly(ethylene glycol diacid) (PEG diacid) obtained by reacting
poly(ethylene glycol) (PEG) (Mw=600) with succinic anhydride. The
PCL-PEG600-PCL diol triblock copolymers were then acrylated with
acryloyl chloride to produce PCL-PEG600-PCL diacrylates (PCE6dA) at low
temperature. The effect of the crosslinker content on the swelling behaviors
and physical properties for the poly(HEMA) hydrogels were, thermal
behavior, swelling ratio, and morphological characteristics as well as
biodegradability of the presented gels were investigated. The results showed
that the swelling ratio of the gel in deionized water decreased with an
increase of the content of crosslinker (PCE6dA) segment in the poly(HEMA)
hydrogels. And the effect that properties of the gels crosslinked with
hydrophobic PCE6dA added. The results also showed that the gels
crosslinked with PCE6dA had higher mechanical strength and crosslinking
density than the gels crosslinked with EGDMA. The gel were crosslinked
with PCE6dA enhance the biodegradable.
The final part of thesis reports A series of biodegradable porous hydrogels, based on biocompatible
2-hydroxyethyl methacrylate (HEMA) and a crosslinker of ABA type
amphiphilic triblock copolymers were synthesized by the condensation of
hydrophobic polycaprolactone diol (PCL diol) with hydrophilic dicarboxy
poly(ethylene oxide) (PEG diacid) obtained by reacting poly(ethylene glycol
diacid) (PEG diacid) (Mw=2000) with succinic anhydride. The
PCL-PEG2000-PCL diol triblock copolymers were then acrylated with
acryloyl chloride to produce PCL-PEG2000-PCL diacrylates (PCE20dA) at
low temperature. The effect of the crosslinker content on the swelling
behaviors and physical properties, thermal behavior, and morphological
characteristics as well as biodegradability of the presented gels were
investigated. The results showed that the swelling ratio of the gel in
deionized water decreased with an increase of the content of crosslinker
(PCE20dA) segment in the poly(HEMA) hydrogels. And the effect that
properties of the gels crosslinked with hydrophobic PCE20dA added. The
results also showed that the gels crosslinked with PCE20dA had higher
mechanical strength and crosslinking density than the gels crosslinked with
EGDMA. The gel were crosslinked with enhance the biodegradable.
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