| Summary: | 博士 === 臺北醫學大學 === 藥學系(博士班) === 96 === So far, there are still many traditional Chinese medical theories and practices not supported with good enough scientific evidences. We are interested in the mechanism involved in purgation that traditional Chinese doctors used when their patients suffered with internal heat, stagnation, and fullness syndromes. Three Chen-Chi-Tang decoctions (CCTD), including Ta-Chen-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT), Tiao-Wei-Chen-Chi-Tang (TWCCT) are three famous purgative formulas In this study, we first conducted a systemic review for evaluating the clinical efficacy of these purgative decoctions on gastrointestinal problems and obesity and hyperlipidemia. We also designed many in vitro and in vivo studies in order to delineate the efficacy and underlying mechanisms involved in purgation. From the systemic review, there is moderate evidence to support the efficacy of CCTD (especially TCCT) in the management of gastro-intestinal problems, but most of the studies do not support anti-obesity effect of purgative decoctions, and clinical evidence of purgatives on hyperlipidemia is still controversial. Through in vitro and in vivo experiments, we have shown that TCCT is a potent anti-inflammatory agent, and XCCT is a potent anti-oxidantant. Inflammation and oxidative stress are two pathophysiological processes involved in many diseases suffered by modern man today. Future clinical application of CCTDs may based on these findings in order to improve the efficacy of these traditional Chinese medicine in the present world.
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