| Summary: | 碩士 === 臺北醫學大學 === 保健營養學研究所 === 96 === Sesamin, a major lignan in sesame seeds and oil, has been known to increase β-oxidation and reduce lipogenesis. In this study, 30 sprague-dawley rats were fed with pure AIN-93G diet (standard diet) and 30 rats were fed with high fat diet (modified from AIN-93G containing 45% calories from soybean oil). After 4 weeks to induce obesity, rats were assigned to 6 groups: N0 (standard diet without sesamin), N1 (standard diet with 0.1% sesamin), N5 (standard diet with 0.5% sesamin), F0 (high fat diet without sesamin), F1 (high fat diet with 0.1% sesamin), F5 (high fat diet with 0.5% sesamin). The rats were weighted weekly and sacrificed after 4 weeks of experiment. Results found that there were significantly reducing in body weight, epididymal adipose tissue and adipocyte size in group F5. Supplement with sesamin led to significantly increase serum HDL-C and decrease plasma triglyceride, LDL-C, non-esterified fatty acid. Insulin sensitivity had also been improving in F5 group. Besides, there were significantly reducing in liver triglyceride and total cholesterol concentration. The enzyme activities of fatty acid synthase and acetyl CoA carboxylase were significantly decreasing in group F5 and acyl CoA oxidase, carnitine palmitoyltransferase were significantly increasing in group F1 and F5. Therefore, we concluded that sesamin can improve lipid metabolism and prevent the accumulation of white adipose tissue.
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