A study of protein function-function correlation

• Main Authors: WALTER GUI, 邱金水
• Other Authors: KA-LOK NG
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/40704103731646545207

碩士 === 亞洲大學 === 生物資訊學系碩士班 === 96 === The main purpose of this research is to derive a set of rules for protein function and protein function correlation. This set of relations is used to predict the biological functions of a protein given that it interacts with another protein having well-define functions. The calculation is based on modeling the protein-protein interaction data by the protein function combination model. It is found that certain types of protein functions tend to correlated with each other, for example, our calculations suggested that the most likely functional correlation pair is protein having transcriptional function interacts with protein has transcriptional function. Randomized version of the function combination model is performed in order to justify the function-function correlation (FFC) calculation. The correlation strength of two protein functions are compared to its randomized counterpart, hence, resulted in a scoring value to rank the relative importance of a FFC. A web based service is set up to provide the following functionality, (i) a ranking list of FFC, (ii) the relative strength of a FFC, and (iii) a prediction service for protein function. The URL address of the service is http://210.70.82.82/ffc.