| Summary: | 碩士 === 大仁科技大學 === 製藥科技研究所 === 96 === It has been raised the public concern on human exposure to the emerging compounds, such as polybrominated diphenyl ethers (PBDEs), in the whole world. The organobromine chemicals are lipophilic endocrine disruptors with high resistance to biodegradation in the environment. The aim of this study was conducted to measure PBDE levels in breast milk of the general population gathered from Pingtung area and to examine the associations between PBDEs exposure and demographic measurements of mothers and infants. Study participants were healthy women recruited from Pingtung area between April and October 2007. Seven congener levels of PBDEs (BDE-47, 49, 99, 126, 153, 191, 209) in 20 breast milk samples were measured by a gas chromatography with a high resoluteion mass spectrometer (GC/Ms). The mean level of PBDEs in breast milk was 2650 ± 2580 pg/g lipid. The highest spearman correlation coefficient was found to be 0.893 (p<0.001) between BDE-47 and BDE-99 in breast milk. The levels of PBDEs were not significantly correlated with maternal age, pre-pregnant body mass index (BMI), parity, and lipid content in breast milk. Milky PBDE level was higher in women with the longest menstrual cycle length longer than 40 days versus less than 40 days (p=0.004). Women with education level lower than high school had the significantly higher magnitude of BDE-99 compared to women with the higher education level (p=0.032). Body burden of BDE-153 in women was increased with the increased head circumference of their offspring (r=0.458, p=0.042). We could not conclude our finding because the sample size was small (n=20). Owing to few environmental monitoring and epidemiological data of PBDEs, longitudinal and continuous studies will be encouraged in Taiwan.
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