Effects of cranberry on the lipid and oxidant status in patients with type 2 diabetes mellitus

• Main Authors: Chia-wen Lin, 林珈汶
• Other Authors: Yin-Ching
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/85295275842138220277

碩士 === 靜宜大學 === 食品營養研究所 === 96 === Abstract The antioxidants in fruits and vegetables have been shown to inactivate the reactive oxygen species that involved in initiation and progression of human diseases or cancers. Cranberry is rich in phenolic phytochemicals such as phenolic acids, flavonoids and anthocyanins, which show benefits to decrease of blood lipids and enhancement of antioxidant capacity. However, it is not clear whether cranberry has health benefits in patients with type 2 diabetes mellitus. The aim of this study was to determine whether daily consumption of cranberry could modulate the levels of blood glucose, blood lipid, and antioxidant status in type 2 diabetes mellitus subjects. Diabetes outpatient subjects in Taichung Veterans General Hospital, with the HbA1C level between 7.0 %-10.0 % and triglyceride < 400 mg/dL were enrolled in this study. Patients were randomized and double-blind divided into control (n=15) or experimental group (n=15). The experimental group was supplemented with 3 times of capsule content of 500 mg cranberry per day, while the control group was offered the placebo for continuous 12 weeks. The anthropometric values, dietary intakes, hematological and biochemical parameters, oxidative and inflammatory factors were evaluated before and after the experiment. The results showed that the anthropometric values did not differ during the experimental period. And the intake of sodium and cholesterol were decreased. Blood sugar, HbA1C, fructosamine, and insulin levels in patients supplemented with cranberry were decreased (no-significant difference). The level of blood lipids, cranberry supplementation significantly decreased the total cholesterol, and low density lipoprotein cholesterol (LDL-C) (P < 0.01). More important, assimilation of cranberry significantly reduced the malondialdehyde concentration and catalase activity (P < 0.01), and the activity of glutathione peroxidase was elevated. Furthermore, cranberry supplementation did not change the expression of intercellular adhesion molecule (I-CAM) and vascular cell adhesion molecule (V-CAM). In conclusion, our results showed that supplementation of 3 times of capsule content of 500 mg cranberry per day per day for continuous 12 weeks could modulate the lipid profiles and oxidant stress, thus might be beneficial to patients with type 2 diabetes mellitus.