Design and Synthesis of Anti-Breast Cancer Agents

• Main Authors: Yi-Fan Chen, 陳一凡
• Other Authors: Lee-Gin Lin
• Format: Others
• Language: zh-TW
• Published: 2008
• Online Access: http://ndltd.ncl.edu.tw/handle/47161321976221543455

碩士 === 中國文化大學 === 應用化學研究所 === 96 === The dried roots of Salvia miltiorrhiza under the name Tanshen has been used in traditional Chinese medicine (TCM) for the treatment of coronary heart disease, hemorrhage, menstrual disorder, miscarriage, insomnia and swelling. According to literature reports, a lot of tanshinones were isolated and identified from methanolic extracts of S. miltiorrhiza and many of them were also reported to exhibit diverse biological activities such as antitumor, antioxidant, antiplatelet aggregation activities. In our previous studies, neo-tanshinlactone was isolated as minor component from the dried roots of S. miltiorrhiza and showed selective anti-breast cancer activity. Because neo-tanshinlactone showed selective anti-breast cancer activity, this compound may have potential to develop as a new anti-breast cancer drug. In order to further study the structure and activity relationship, in this study, twelve neo-tanshinlactone analogues (7, 8a, 8b, 9, 10a, 10b, 11, 12, 13, 14, 17, 18) were synthesized. These synthesized compounds will be evaluated for anti-breast cancer activity.