| Summary: | 碩士 === 國立臺灣大學 === 臨床牙醫學研究所 === 96 === Background: Overexpression of cellular inhibitor of apoptosis protein 1 (cIAP-1) has been demonstrated in a variety of human cancers and found to be associated with the lymph node metastasis, clinical stage, recurrence, or prognosis of these cancers.
Methods: In this study, we examined the expression of cIAP-1 protein in 73 specimens of oral squamous cell carcinoma (OSCC), 76 specimens of oral epithelial dysplasia (OED), and 31 specimens of normal oral mucosa (NOM) by immunohistochemistry. The cytoplasmic cIAP-1 labeling indices (LIs) in OSCC, OED, and NOM samples were calculated and compared between groups. The correlation between the cytoplasmic cIAP-1 LI in OSCCs and clinicopathological parameters or survival of OSCC patients was analyzed statistically.
Results: The mean cytoplasmic cIAP-1 LIs increased significantly from NOM (23 ± 22%) through OED (50 ± 25%) to OSCC samples (73 ± 17%) (P = 0.000). A significant correlation was found between the higher mean cytoplasmic cIAP-1 LIs and OSCCs with positive lymph node metastasis (P = 0.000) or more advanced clinical stages (P=0.045).
Conclusion: Our results suggest that the increased expression of cIAP-1 is an early event in oral carcinogenesis and the cIAP-1 may be a biomarker for OSCCs. Measuring the amount of cytoplasmic cIAP-1 expression in OSCC samples may predict the oral cancer progression in Taiwan.
Key words: cellular inhibitor of apoptosis protein 1, oral cancer, oral precancer
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