| Summary: | 碩士 === 國立臺灣大學 === 動物學研究所 === 96 === Chronic muscle pain and hyperalgesia induced are disabling and difficult to treat.
Acidic Saline (pH=4.0) injected repeatedly into the gastrocnemius muscle produce
persistent mechanical hyperalgesia and muscle pain in Sprague-Dawley (SD) rats and
many mice strains. The objective of the present project was to test the hypothesis that
activation of amygdala and amygdala T-type calcium channel is necessary in the
development of this chronic hyperalgesia. We used the ERK immunochemistry stain
and positron emission tomography (PET) scanner to demonstrate that activation of the
amygdale in acid induced pain animals. Cannula was implanted bilaterally in both
side of the amygdala of SD rats and two kinds of T-type calcium channel blockers, namely, mibefradil and ethosuximide, were injected. SD rats showed decrease of
threshold to mechanical stimulation after repeated injection of acidic saline, and this sensitization phenomenon was prevented by pre-treatment of T-type calcium channel blockers in amygdale. The preliminary results suggest that amygdala play an important role in the expression of chronic muscle pain.
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